2 articles featuring Humulene
Even with the use of 5-HT3 and NK1 receptor antagonists, chemotherapy-induced nausea and vomiting (CINV) remains a hurdle in oncology. When patients experience symptoms that are refractory to standard anti-emetics, we may look at the endocannabinoid system (ECS) and how it regulates the body’s emetic pathways. The clinical potential of cannabinoids in this context involves their interaction with specific receptors in both the central and peripheral nervous systems.
The Area Postrema sits in the medulla oblongata, functioning as the body’s primary chemoreceptor trigger zone. Because this structure lacks a standard blood-brain barrier, it is uniquely vulnerable—and responsive—to bloodborne toxins. When cytotoxic chemotherapy drugs like Cisplatin or Doxorubicin enter the bloodstream, they trigger this sensor, which may trip the body’s emetic (vomiting) reflex.