Question 1

What is Nerolidol?

Accepted Answer

A sesquiterpene (larger molecule) found in jasmine and tea tree. Nerolidol enhances skin absorption, which is why it is used in transdermal cannabis products. In flower, it contributes to sedating, deeply relaxing effects and a woody, fresh aroma. It is one of the terpenes associated with "creeper" strains — effects that build slowly over 15-20 minutes.

Question 2

What are the effects of Nerolidol?

Accepted Answer

Nerolidol is associated with the following effects: Sedating, Relaxing, Calming.

Question 3

What does Nerolidol smell like?

Accepted Answer

Nerolidol has an aroma described as: Woody, earthy, fresh bark with floral notes.

Question 4

What are the therapeutic uses of Nerolidol?

Question 5

What is the science behind Nerolidol?

Accepted Answer

**Classification:** Acyclic sesquiterpene alcohol (C₁₅H₂₆O). Exists as two geometric isomers (cis and trans-nerolidol) that differ in bioactivity. The trans isomer predominates in cannabis and demonstrates stronger pharmacological activity.

**Boiling Point:** 122°C / 252°F (cis); 276°C / 529°F (trans). The wide boiling point separation between isomers means vaporizer temperature significantly affects which form is delivered.

**Receptor & Molecular Activity**
Nerolidol is the most potent antiparasitic terpene characterized in cannabis research. It disrupts the cell membranes of protozoal parasites (Leishmania, Plasmodium/malaria, Trypanosoma) through a membrane intercalation mechanism — embedding in lipid bilayers and disrupting membrane integrity. This is not a receptor-mediated effect but a direct physicochemical interaction with membrane lipids.

Nerolidol also demonstrates sedative CNS activity in rodent models via an undefined receptor mechanism (barbiturate sleep time potentiation has been observed). Its skin permeation-enhancing properties parallel bisabolol's — nerolidol increases the transdermal flux of hydrophilic compounds by disrupting the lipid structure of the stratum corneum.

**Entourage Dynamics**
Nerolidol co-occurs frequently with myrcene in deeply sedative profiles. Its penetration-enhancing effect in topical applications complements bisabolol's similar activity. In oral/inhalation routes, its sedative potentiation of CNS depressants is relevant — nerolidol-dominant profiles may produce stronger sedation than the cannabinoid profile alone would predict.

**Clinical Research Context**
Antimalarial activity is the most clinically relevant finding — nerolidol has demonstrated efficacy against Plasmodium falciparum (the malaria parasite) in both in vitro and rodent models. Antileishmanial activity has been documented. The permeation-enhancing data is well-established in pharmaceutical delivery research.

Question 6

Where else is Nerolidol found outside of cannabis?

Accepted Answer

Nerolidol is also found in: Jasmine, Tea tree, Ginger, Lavender.

Question 7

What is the boiling point of Nerolidol?

Accepted Answer

The boiling point of Nerolidol is 122°C (252°F).

Nerolidol

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